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I'm was having a similar problem today and am not using @ngx-translate/core so that didn't explain the issue for me.

It turned out that my app was having a runtime issue on load, and making further edits within the ng 4 app didn't compile on save. After I fixed the run time issue compileOnSave resumed functioning as normal. Not sure if that helps..i.e. ensure there are no run-time errors interfering with normal behavior of compileOnSave.

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