yes, this is possible. see cursor. example (from that link). basically you set cursor option for the series:

plotoptions: {
            series: {
                cursor: 'pointer',
                events: {
                    click: function() {
                        alert('you just clicked the graph');

if you want to make the whole chart clickable then you need to handle mouse hover/over. but then you may lose detail on where you are clicking (want to click series point but now you cant because you captured it on the "top" layer).

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